InSight Biopharmaceuticals - Scientific Publications

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Scientific Publications

In addition to InSight’s development activities the company maintains ongoing research in the Heparanase field. Here are some of InSight's recent publications:

•	Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass (J. Cell. Physiol. 207:784792, 2006)

•	Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models (The FASEB J. 19:211-221, 2005)

•	Decreased expression of heparanase in glioblastoma multiforme (J. Neurosurg. 102:513-521, 2005)

•	Phenotypic knockout of heparan sulfates in myotubes impairs excitation-induced calcium spiking (The FASEB J. 17: 878-880, 2003)

•	Human heparanase is localized within lysosymes in stable form (Exp. Cell Res. 281:50-62, 2002)

•	Activation, Processing and trafficking of extracellular heparanase by primary human fibroblasts (J. Cell Science 115: 2179-2187, 2002)

•	Heparanase expression in human leukemias is restricted to acute myeloid leukemias (Exp Hematol. 2002 Jan;30(1):34-41)

•	Secretion and expression pattern of human and chicken heparanases are determined by their signal peptide sequences (J Biol Chem. 2001 Aug 3;276(31):29178-87)

•	Molecular properties and involvement of heparanase in cancer progression and mammary gland morphogenesis (J. Mammary Gland Biology and Neoplasia 6: 311-322, 2001)

•	Heparanase as a mediator of angiogenesis: mode of action (FASEB J. 2001 Jul;15(9):1661-3)

•	Heparanase expression in primary and metastatic pancreatic cancer (Cancer Research 61: 4655-4659, June 15, 2001)

•	Expression of Heparanase in normal, dysplastic and neoplastic human colonic mucosa and stroma: evidence for its role in colonic tumorigenesis (Am. J. Pathol. 157: 1167-175, October 2000)

•	Mammalian Heparanase: Gene cloning, expression and function in tumor progression and metastasis (Nat Med. 1999 Jul;5(7):793-802)